PI3P is dephosphorylated to PI by MTM[2] at the early endosome membrane At the early endosome membrane, myotubularin (MTM1), myotubularin-related protein 2 (MTMR2), and myotubularin-related protein 4 (MTMR4) dephosphorylate phosphatidylinositol 3-phosphate (PI3P) to phosphatidylinositol (PI).<br><br>The following lists the above proteins with their corresponding literature references: MTM1 (Cao et al. 2007, Cao et al. 2008, Kim et al. 2002), MTMR2 (Cao et al. 2008, Kim et al. 2002), and MTMR4 (Lorenzo et al. 2006, Zhao et al. 2001). Authored: Williams, MG, 2011-10-18 EC Number: 3.1.3.64 Edited: Williams, MG, 2011-08-12 Pubmed11302699 Pubmed11733541 Pubmed16787938 Pubmed17651088 Pubmed18524850 Reactome Database ID Release 431676141 Reactome, http://www.reactome.org ReactomeREACT_121390 Reviewed: Wakelam, Michael, 2012-05-14