STAT5 tyrosine phosphorylation Authored: Jupe, S, 2010-10-14 EC Number: 2.7.10 Edited: Jupe, S, 2011-06-10 Pubmed8197455 Pubmed8732683 Pubmed9121492 Reactome Database ID Release 431168394 Reactome, http://www.reactome.org ReactomeREACT_111218 Reviewed: Herington, AC, 2011-06-13 Reviewed: Waters, MJ, 2011-06-23 Stat5 tyrosine phosphorylation was seen in response to GH in CHO cells expressing mouse GHR forms capable of binding JAK2 (Smit et al. 1996). Similar results were obtained using the porcine receptor (Wang et al. 1996). Thus Jak2 phosphorylates Stat5, the phosphorylated monomers form dimers and translocate to the nucleus (Darnell et al. 1994). has a Stoichiometric coefficient of 2 Growth Hormone:Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:p-STAT5 Growth Hormone:Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:STAT5