Metalloprotease cleavage of GHR Approximately half of circulating GH is bound to Growth Hormone Binding Protein ((GHBP) Herington et al. 1986), a soluble fragment of the Growth Hormone Receptor (Baumann et al. 1986) formed when the extracellular region is proteolytically cleaved (Leung et al. 1987). This cleavage is mediated by metalloproteases such as TACE (ADAM17, Zhang et al. 2000). The membrane-bound remnant is subsequently degraded by the gamma-secretase complex (Cowan et al. 2005). Authored: Jupe, S, 2010-10-14 EC Number: 3.4.24 Edited: Jupe, S, 2011-06-10 Pubmed11108241 Pubmed15743767 Pubmed16037128 Pubmed2825030 Pubmed3711337 Pubmed3940261 Reactome Database ID Release 431168777 Reactome, http://www.reactome.org ReactomeREACT_111197 Reviewed: Herington, AC, 2011-06-13 Reviewed: Waters, MJ, 2011-06-23