SHP1 (PTPN6) dephosphorylates JAK2 Authored: Jupe, S, 2010-10-14 EC Number: 3.1.3.48 Edited: Jupe, S, 2011-06-10 Pubmed9111009 Reactome Database ID Release 431169188 Reactome, http://www.reactome.org ReactomeREACT_111048 Reviewed: Herington, AC, 2011-06-13 Reviewed: Waters, MJ, 2011-06-23 SHP1 (PTPN6) dephosphorylates GH-activated JAK2, limiting the duration of signaling (Hackett et al. 1999). has a Stoichiometric coefficient of 2 Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SHP1 Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-JAK2 dimer:SHP1