PI(3,4,5)P3 is dephosphorylated to PI (4,5)P2 by PTEN at the plasma membrane At the plasma membrane, phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase aka phosphatase and tensin homolog (PTEN) dephosphorylates phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) to phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) (Maehama & Dixon 1998, Myers et al. 1998, Das et al. 2003). Authored: Williams, MG, 2011-10-18 EC Number: 3.1.3.67 Edited: Williams, MG, 2011-08-12 Pubmed12808147 Pubmed9593664 Pubmed9811831 Reactome Database ID Release 431676191 Reactome, http://www.reactome.org ReactomeREACT_121053 Reviewed: Wakelam, Michael, 2012-05-14