PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane At the plasma membrane, phosphatidylinositol-5-phosphate 4-kinase type-2 alpha (PIP4K2A) and beta (PIP4K2B) homodimers and heterodimers (Clarke et al. 2010), along with phosphatidylinositol-4-phosphate 5-kinase type-1 alpha (PIP5K1A), beta (PIP5K1B), and gamma (PIP5K1C) phosphorylate phosphatidylinositol 3-phosphate (PI3P) to phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2).<br><br>The following lists the above proteins with their corresponding literature references: PIP4K2A (Zhang et al. 1997, Rameh et al. 1997, Clarke et al. 2008), PIP4K2B (Zhang et al. 1997, Rameh et al. 1997), PIP5K1A (Zhang et al. 1997, Tolias et al. 1998), PIP5K1B (Zhang et al. 1997, Tolias et al. 1998), and PIP5K1C (Wenk et al. 2001, Di Paolo et al. 2002). Authored: Williams, MG, 2011-10-18 Edited: Williams, MG, 2011-08-12 Pubmed11604140 Pubmed12422219 Pubmed18753295 Pubmed19896968 Pubmed9211928 Pubmed9367159 Pubmed9660759 Reactome Database ID Release 431676145 Reactome, http://www.reactome.org ReactomeREACT_121352 Reviewed: Wakelam, Michael, 2012-05-14