STAT1/3 dimers translocate to the nucleus Authored: Ray, K, 2010-12-13 Edited: Jupe, S, 2010-12-10 In untreated cells both STAT1 and STAT3 are distributed diffusely in the cytoplasm and the nucleus. A few minutes after IL-6 treatment both are preferentially located in the nucleus. This translocation is transient; after 2 h the distribution is comparable to that of untreated cells (Zhang et al. 1995). The mechanism by which STATs enter the nucleus is likely to be mediated by importins via nuclear pore complexes (NPCs) (Reich & Liu, 2006). Pubmed16868551 Pubmed7701321 Reactome Database ID Release 431112587 Reactome, http://www.reactome.org ReactomeREACT_27303 Reviewed: Rose-John, S, 2011-02-11 Activated STAT1/3 homo and heterodimers Activated STAT1/3 homo and heterodimers