Interleukin-7:IL7RA:JAK1 binds Gc:JAK3 Authored: Ray, KP, 2010-05-17 Edited: Jupe, S, 2011-05-06 Pubmed8128231 Pubmed8266077 Reactome Database ID Release 43449958 Reactome, http://www.reactome.org ReactomeREACT_115695 Reviewed: Puck, J, 2011-11-03 Studies using chemical crosslinking and monoclonal antibodies specific for the IL-2 receptor gamma chain (Gc) demonstrated that Gc participates in the functional high-affinity interleukin-7 receptor complex (Noguchi et al. 1993, Kondo et al. 1994). <br><br>The membrane-associated Gc chain interacts with the intermediate 1:1 IL7:IL7R complex, forming the active ternary complex, which binds IL7 with a 3-fold higher affinity (Kd =80 pM). IL7:IL7RA:JAK1 IL7:IL7RA:JAK1:IL2RG:JAK3 IL2RG:JAK3