Growth hormone receptor dimerizes Authored: Jupe, S, 2010-10-14 Edited: Jupe, S, 2011-06-10 Pubmed16116438 Pubmed16820415 Pubmed1948064 Pubmed8343952 Reactome Database ID Release 43982775 Reactome, http://www.reactome.org ReactomeREACT_111208 Reviewed: Herington, AC, 2011-06-13 Reviewed: Waters, MJ, 2011-06-23 The growth hormone receptor forms dimers (Cunningham et al. 1991) that subsequently signal via JAK2 (Argetsinger et al. 1993). Early studies suggested that dimerization occured following ligand binding, but it is now generally accepted that dimerization is independent of ligand binding and involves the transmembrane and juxtamembrane domains (van den Eijnden et al. 2006, Brown et al. 2005). has a Stoichiometric coefficient of 2 Growth Hormone Receptor:JAK2 Growth Hormone Receptor-JAK2 dimer