p-S585-IL3RB binds 14-3-3 proteins Authored: Ray, KP, 2010-05-17 Edited: Jupe, S, 2010-08-06 Pubmed10477722 Pubmed10949031 Reactome Database ID Release 43912757 Reactome, http://www.reactome.org ReactomeREACT_23870 Reviewed: Hercus, TR, 2010-09-06 Reviewed: Lopez, AF, 2010-09-06 The common beta chain (Bc), binds 14-3-3 zeta at a site that requires phosphorylation of Serine 585 (Stomski et al. 1999). Bc modifications that prevent Ser-585 phosphorylation do not recruit 14-3-3 zeta (Guthridge et al. 2000). High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc