IL6:sIL6R IL6:sIL6R binds sgp130 Authored: Ray, K, 2010-12-13 Edited: Jupe, S, 2010-12-10 Pubmed11121117 Reactome Database ID Release 431067676 Reactome, http://www.reactome.org ReactomeREACT_27205 Reviewed: Rose-John, S, 2011-02-11 Soluble gp130 binds to circulating IL6:sIL6R, preventing binding to gp130 on the plasma membrane, thereby specifically inhibiting IL-6 trans-signaling (Jostock et al. 2001). This protein is to enter clinical development for the treatment of inflammatory diseases. It can be anticipated that less beneficial activities of IL-6 will be blocked by soluble gp130 than by global blockade of IL-6 with neutralizing monoclonal antibodies to IL-6 or IL-6R IL6:sIL6R:sgp130