Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs Phosphorylation of gp130 Activated JAKs are believed to be responsible for phosphorylating the cytoplasmic region of gp130 (Wang & Fuller 1994, Reich & Liu 2006) creating docking sites for adaptor and downstream signaling molecules, in particular the STAT factors STAT1 and STAT3. Several phosphotyrosine residues of gp130 are docking sites for STAT factors (Stahl et al. 1995, Gerhartz et al. 1996), Tyr-759 phosphorylation allows recruitment of the phosphatase SHP2. Authored: Ray, K, 2010-12-13 Edited: Jupe, S, 2010-12-10 Pubmed16868551 Pubmed7812050 Pubmed7871433 Pubmed8662591 Reactome Database ID Release 431112510 Reactome, http://www.reactome.org ReactomeREACT_27189 Reviewed: Rose-John, S, 2011-02-11 has a Stoichiometric coefficient of 20 IL6 receptor hexamer:Activated JAKs