Tyrosine phosphorylation of STATs by IL6 receptor Authored: Ray, K, 2010-12-13 EC Number: 2.7.10.2 Edited: Jupe, S, 2010-12-10 IL-6 activates the tyrosine phosphorylation of STATs (Akira et al. 1994, Zhong et al. 1994) by JAKs (Hemmann et al. 1996) at a site that is essential for dimerization. For STAT1 this is tyrosine-701, for STAT3 tyrosine-705 (Kaptein et al. 1996, Shuai et al. 1994). Tyrosine phosphorylation leads to homo- or heterodimerization and translocation to the nucleus (Zhong et al. 1994), where the dimers bind to enhancers of interleukin-6- inducible genes e.g. acute phase protein genes, resulting in transcriptional activation. Pubmed7510216 Pubmed7512451 Pubmed8140422 Pubmed8626374 Pubmed8662795 Reactome Database ID Release 431112602 Reactome, http://www.reactome.org ReactomeREACT_27203 Reviewed: Rose-John, S, 2011-02-11 has a Stoichiometric coefficient of 2 Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1/3 Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1/3