LTB4 is oxidised to 12-oxoLTB4 by PTGR1 Authored: Williams, MG, 2012-02-24 Edited: Williams, MG, 2012-02-24 Prostaglandin reductase 1 (PTGR1) aka LTB4DH metabolizes eicosanoids by catalysing the oxidation of leukotriene B4 (LTB4) to form 12-oxo-Leukotriene B4 (12-oxoLTB4) aka 12-Keto-LTB4. The gene was originally cloned as leukotriene B4 12-hydroxydehydrogenase (LTB4DH) but was later discovered to have dual functionality as a prostaglandin reductase (Yokomizo et al. 1996). This reaction has been inferred from a reaction in pigs (Yokomizo et al. 1993, Ensor et al. 1998). Pubmed8394361 Pubmed8576264 Pubmed9461497 Reactome Database ID Release 432161567 Reactome, http://www.reactome.org ReactomeREACT_150449 Reviewed: Rush, MG, 2012-11-10