Oxidation of arachidonic acid to 5-HpETE Arachidonate 5-lipoxygenase (ALOX5) catalyzes the formation of leukotriene A4 (LTA4) from arachidonic acid in a two-step process. First, arachidonic acid AA is oxidized to form 5S-hydroperoxyeicosatetranoic acid (5S-HpETE) (Rouzer et al. 1988, Rouzer & Samuelsson 1987, Rouzer et al. 1986). Arachidonic acid is oxidised to 5S-HpETE by ALOX5 Authored: Jassal, B, 2008-10-01 13:18:42 EC Number: 1.13.11.34 Edited: Jassal, B, 2008-04-21 14:30:22 Pubmed3006030 Pubmed3118366 Pubmed3164719 Reactome Database ID Release 43265296 Reactome, http://www.reactome.org ReactomeREACT_15337 Reviewed: Rush, MG, 2012-11-10