PGH2 is reduced to PGF2a by FAM213B Authored: Williams, MG, 2012-02-24 Edited: Williams, MG, 2012-02-24 Prostamide/prostaglandin F synthase, FAM213B and thioredoxin (TXN) are the proteins involved in the reduction of prostaglandin H2 (PGH2) to prostaglandin F2alpha (PGF2a) (Moriuchi et al. 2008, Yoshikawa et al. 2011). This reaction has been inferred from an event in mice. An additional way of achieving this reaction involves the protein aldo-keto reductase family 1 member C3 (AKR1C3) aka PGFS. Pubmed18006499 Pubmed20950588 Reactome Database ID Release 432161612 Reactome, http://www.reactome.org ReactomeREACT_150194 Reviewed: Rush, MG, 2012-11-10