PGH2 is isomerised to PGE2 by PTGES Authored: Williams, MG, 2012-02-24 EC Number: 5.3.99.3 Edited: Williams, MG, 2012-02-24 Prostaglandin E synthase (PTGES) requires glutathione (GSH) as an essential cofactor for its enzymatic activity, and together they isomerise prostaglandin H2 (PGH2) to prostaglandin E2 (PGE2) (Jegerschold et al. 2008). After PGH2 has been produced by the prostaglandin G/H synthases (PTGS1 and 2) on the lumenal side of the endoplasmic reticulum, it diffuses through the membrane to the active site of PTGES located on the cytoplasmic side. Pubmed18682561 Reactome Database ID Release 432161660 Reactome, http://www.reactome.org ReactomeREACT_150407 Reviewed: Rush, MG, 2012-11-10