PGH2 is isomerised to TXA2 by TBXAS1 Authored: Jassal, B, 2008-10-01 13:18:42 EC Number: 5.3.99.5 Edited: Jassal, B, 2008-05-19 12:57:01 Pubmed11465543 Pubmed7925341 Reactome Database ID Release 4376500 Reactome, http://www.reactome.org ReactomeREACT_1377 Reviewed: Rush, MG, 2012-11-10 Thromboxane synthase (CYP5A1) mediates the isomerization of prostaglandin H2 to thromboxane A2 Thromboxane synthase (TBXAS1) aka CYP5A1 mediates the isomerization of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2) (Miyata et al. 2001, Chevalier et al. 2001). This reaction is not coupled with any P450 reductase proteins nor consumes NADPH.