15k-PGE2/F2a is reduced to dhk-PGE2/F2a by PTGR1 Authored: Williams, MG, 2012-02-24 Edited: Williams, MG, 2012-02-24 Prostaglandin reductase 1 (PTGR1) aka LTB4DH is a 13-prostaglandin reductase which metabolises eicosanoids by catalysing NADH/NADPH-dependant double bond reduction in 15-keto-prostaglandin E2 (15k-PGE2) and F2alpha (15k-PGF2a) to produce 13,14-dihydro-15-keto-prostaglandin E2 (dhk-PGE2) and F2alpha (dhk-PGF2a) respectively (Yokomizo 1996). This has been inferred from the reaction event in mice involving prostaglandin reductase 2 (Ptgr2) (Chou et al. 2007). Pubmed17449869 Pubmed8576264 Reactome Database ID Release 432161692 Reactome, http://www.reactome.org ReactomeREACT_150174 Reviewed: Rush, MG, 2012-11-10 15k-PGE2/F2a dhk-PGE2/F2a