PGH2 is isomerised to PGI2 by PTGIS Authored: Jassal, B, 2008-10-01 13:18:42 EC Number: 5.3.99.4 Edited: Jassal, B, 2008-05-19 12:57:01 Prostacyclin synthase (CYP8A1) mediates the isomerization of prostaglandin H2 to prostaglandin I2 Prostacyclin synthase (PTGIS) aka CYP8A1 mediates the isomerisation of prostaglandin H2 (PGH2) to prostaglandin I2 (PGI2) aka prostacyclin (Wada et al. 2004). This reaction is not coupled with any P450 reductase proteins nor consumes NADPH. Pubmed15115769 Reactome Database ID Release 4376496 Reactome, http://www.reactome.org ReactomeREACT_1841 Reviewed: Rush, MG, 2012-11-10