Elongation of arachidonyl-CoA to docosatetraenoyl-CoA Arachidonyl-CoA undergoes a two-carbon chain elongation on the carboxyl end to form docosatetraenoyl-CoA (DTA-CoA/Adrenic acid/7,10,13,16-docosatetraenoic acid (7,10,13,16-22:4(n-6)). This reaction is catalyzed by the enzymes ELOVL5 or ELOVL2. Malanoyl-CoA provides the additional two carbons required for elongation. Docosatetraenoyl-CoA is further metabolized by cyclooxygenases (COX), lipoxygenases (LO) and cytochrome P450s (CYP450s) to dihomo (DH) eicosanoids (Kopf et al. 2010, Leonard et al. 2004). Authored: Garapati, P V, 2012-01-11 Edited: Garapati, P V, 2012-01-11 Pubmed10970790 Pubmed14636670 Pubmed20038752 Reactome Database ID Release 432046083 Reactome, http://www.reactome.org ReactomeREACT_121099 arachidonoyl-CoA + malonyl-CoA => 3-oxo-(7,10,13,16)-docosatetraenoyl-CoA + CO2 + CoASH [ELOVL5] has a Stoichiometric coefficient of 2