Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA Authored: Garapati, P V, 2012-01-11 EC Number: 1.14.19.3 Edited: Garapati, P V, 2012-01-11 Pubmed11988075 Pubmed12562861 Pubmed12713571 Pubmed8386433 Reactome Database ID Release 432046096 Reactome, http://www.reactome.org ReactomeREACT_121304 The first major step in the metabolism of linoleic acid (LA) is desaturation of delta 9,12-octadecadienoyl CoA/linoleoyl CoA (LA-CoA) to delta 6,9,12-octodecatrienoyl CoA/gamma-lenoleoyl CoA (GLA-CoA). This step is catalyzed by delta-6-destaurase (fatty acid desaturase-2, FADS2) which introduces a cis-double bond between carbons 6 and 7. This is the rate limiting step in LA metabolism (Horrobin 1993). has a Stoichiometric coefficient of 2