Aspirin acetylates PTGS2 Aspirin (acetylsalicylate) reacts spontaneously with one subunit of PTGS2 dimer (Dong et al. 2011) to acetylate serine residue 516 (Lecomte et al. 1994). The modified enzyme is no longer capable of catalyzing the conversion of arachidonic acid to PGH2, but acquires the ability to convert it to 15R-HETE. Authored: D'Eustachio, P, 2012-06-07 Edited: D'Eustachio, P, 2012-06-07 Pubmed21467029 Pubmed8175750 Reactome Database ID Release 432314686 Reactome, http://www.reactome.org ReactomeREACT_150446 Reviewed: Rush, MG, 2012-11-10 PTGS2 dimer Ac-PTGS2 dimer