Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA Authored: Garapati, P V, 2012-01-11 Edited: Garapati, P V, 2012-01-11 Eicosapentaenoyl-CoA (EPA-CoA) is transformed to docosapentaenoyl-CoA (DPA-CoA/clupanodonic acid; 7,10,13,16,19-22:5(n-3)) by addition of two carbon atoms from malanoyl-CoA. This reaction is catalyzed by the enzymes ELOVL5/2 (Leonard et al. 2004). DPA is quite high in seal oil and may act as an anti-atherogenic factor. DPA has 10-fold greater endothelial cell migration ability than EPA, which is important in wound-healing processes. DPA may act as a precursor for production of the DPA-related D-series of resolvins or neuroprotectins (Kaur et al. 2011). Pubmed12323085 Pubmed12323090 Pubmed14636670 Pubmed20655949 Pubmed8832760 Reactome Database ID Release 432046100 Reactome, http://www.reactome.org ReactomeREACT_121058 has a Stoichiometric coefficient of 2