Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase Authored: Garapati, P V, 2012-01-11 EC Number: 2.8.3.8 Edited: Garapati, P V, 2012-01-11 Pubmed11734571 Pubmed8656081 Reactome Database ID Release 432066788 Reactome, http://www.reactome.org ReactomeREACT_121028 The final step in the beta-oxidation process is the thiolytic cleavage of 1-(3-oxo-6Z,9Z,12Z,15Z,18Z,21Z-tetracosahexaenoyl)-CoA to form docosahexaenoyl-CoA (DHA-CoA). This step is catalysed by both sterol carrier protein X (SCPx) and the classic 3-ketoacyl-CoA thiolase (this reaction) (Ferdinandusse et al. 2001).