PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane At the plasma membrane, Synaptojanin-1 (SYNJ1) and -2 (SYNJ2), inositol polyphosphate 5-phosphatase K (INPP5K) aka SKIP, phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (INPP5J) aka PIPP dephosphorylate phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) to form phosphatidylinositol 4-phosphate (PI4P). SYNJ1/2 both have an N-terminal Sac1-like domain, a central 5-phosphatase domain and a C-terminal proline-rich segment, with this latter part being the most divergent part of the protein sequence.<br><br>The following lists the above proteins with their corresponding literature references: SYNJ1 (Johenning et al. 2004, Haffner et al. 1997, Guo et al. 1999, Mani et al. 2007), SYNJ2 (Malecz et al. 2000), INPP5K (Injuin et al. 2000, Gurung et al. 2003), and INPP5J (Gurung et al. 2003, Mochizuki & Takenawa 1999). Authored: Williams, MG, 2011-10-18 EC Number: 3.1.3.36 Edited: Williams, MG, 2011-08-12 Pubmed10224048 Pubmed10593988 Pubmed10753883 Pubmed11084340 Pubmed12536145 Pubmed15080793 Pubmed18093523 Pubmed9428629 Reactome Database ID Release 431676177 Reactome, http://www.reactome.org ReactomeREACT_121166 Reviewed: Wakelam, Michael, 2012-05-14