Destruction of Ubiquitinated HIF-alpha by the Proteasome Authored: May, B, 2011-03-18 Destruction of ubiquitinated HIF-alpha can occur in both the cytosol and nucleus (Berra et al. 2001). Upon reoxygenation of hypoxic cells HIF-alpha is ubiquitinated in the nucleus and transported to the cytosol in a complex with VHL:ElonginB:ElonginC:CUL2:RBX1 where it is destroyed (Groulx and Lee 2002, Jaakkola et al. 2001, Ivan et al. 2001) Edited: May, B, 2011-03-18 Pubmed11292861 Pubmed11292862 Pubmed11454738 Pubmed12101228 Reactome Database ID Release 431234159 Reactome, http://www.reactome.org ReactomeREACT_120788 Reviewed: Rantanen, Krista, 2012-05-19 RBX1-CUL2-EloB/C-VHL ubiquitin ub-hydroxyPro-HIF-alpha:VHL:EloB/C:CUL2:RBX1