Translocation of HIF-alpha from Cytosol to Nucleus Authored: May, B, 2011-03-18 Edited: May, B, 2011-03-18 HIF-alpha is translocated into the nucleus (Kallio et al. 1998, Depping et al. 2008, Chachami et al. 2009). Importin 4 and importin 7 (Chachami et al. 2009) as well as the importin alpha/beta pathway (Depping et al. 2008) appear to be capable of interacting with HIF-alpha. During hypoxia HIF-alpha accumulates in the nucleus where it associates with CBP and p300 (Kallio et al. 1998). Pubmed18187047 Pubmed19788888 Pubmed9822602 Reactome Database ID Release 431234161 Reactome, http://www.reactome.org ReactomeREACT_120857 Reviewed: Rantanen, Krista, 2012-05-19 HIF-alpha HIF-alpha