Nuclear Export of Ubiquitinated HIF-alpha:VHL:EloB/C:CUL2:RBX1 Complex Authored: May, B, 2011-03-09 Edited: May, B, 2011-03-18 Pubmed12101228 Pubmed9891082 Reactome Database ID Release 431234175 Reactome, http://www.reactome.org ReactomeREACT_121002 Reviewed: Rantanen, Krista, 2012-05-19 When hypoxic cells return to normoxia, HIF-alpha is ubiquitinated in the nucleus and exported to the cytosol (Groulx and Lee 2002). The shuttling of VHL between the nucleus and cytosol is required (Groulx and Lee 2002, Lee et al. 1999). ub-HIF-alpha:VHL:EloB/C:CUL2:RBX1 ub-hydroxyPro-HIF-alpha:VHL:EloB/C:CUL2:RBX1