Phosphorylation of IL2RB Y338 enables SHC recruitment Authored: Ray, KP, 2010-05-17 Edited: Jupe, S, 2010-08-06 Phosphorylation of IL2RB Y338 creates a binding site for the accessory protein SHC, which then becomes tyrosine phosphorylated and recruits the Grb2/Sos and Grb2:Gab2 complexes. Pubmed7499411 Pubmed8643566 Pubmed8700888 Reactome Database ID Release 43452091 Reactome, http://www.reactome.org ReactomeREACT_27317 Reviewed: Dooms, H, 2011-03-17 Reviewed: Villarino, A, 2011-02-11 IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:SHC