Phosphorylated SHC1 recruits GRB2:GAB2 Authored: Ray, KP, 2010-05-17 Edited: Jupe, S, 2010-08-06 Phosphorylated Shc recruits Grb2 and Gab2, probably by binding to Grb2 in the Grb2:Gab2 complex. Gab2 associates with Grb2, Shc, Shp2 and the p85 subunit of PI3K (Gu et al. 1998). The association of Grb2 with Gab2 has been suggested to be constitutive (Gu et al. 2000, Kong et al. 2003, Harkiolaki et al. 2009), so Gab2 may be recruited to Shc1 with Grb2. Alternatively, Gab2 has been suggested to associate constitutively with Shc (Kong et al 2003). In either case, the result is a complex of Shc:Grb2:Gab2. Gab2 binding to p85 (Gu et al. 1998) links Shc1 to PI3K activity and subsequent activation of kinases such as Akt (Gu et al. 2000). Pubmed10982827 Pubmed12464621 Pubmed19523899 Pubmed8084588 Pubmed9885561 Reactome Database ID Release 43453104 Reactome, http://www.reactome.org ReactomeREACT_23856 Reviewed: Dooms, H, 2011-03-17 Reviewed: Villarino, A, 2011-02-11 has a Stoichiometric coefficient of 4 Interleukin receptor compexes with activated Shc:GRB2:GAB2 Interleukin receptor complexes with activated SHC1 GRB2:GAB2