Gab2 binds the p85 subunit of Class 1A PI3 kinases Authored: Ray, KP, 2010-05-17 Edited: Jupe, S, 2010-08-06 Pubmed10455108 Pubmed10982827 Pubmed9774657 Pubmed9885561 Reactome Database ID Release 43508247 Reactome, http://www.reactome.org ReactomeREACT_24024 Reviewed: Dooms, H, 2011-03-17 Reviewed: Villarino, A, 2011-02-11 Shc promotes Gab2 tyrosine phosphorylation via Grb2 (Gu et al. 2000). This promotes binding of Gab2 to p85alpha, a component of Class 1A PI3Ks (Gu et al. 1998). JAK1 may also be involved in PI3K recruitment (Migone et al. 1998). Binding of p85 activates PI3K kinase activity, with consequent effects on many processes including Akt activation. This is one of two mechanisms described for the recruitment of PI3K to the IL-3/IL-5/GM-CSF receptors, the other is mediated by Serine-585 phosphorylation of the common beta chain. has a Stoichiometric coefficient of 4 Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 p85-containing Class 1A PI3Ks