Phosphorylated SHC recruits GRB2:SOS1 Authored: Ray, KP, 2010-05-17 Edited: Jupe, S, 2010-08-06 Pubmed1465135 Pubmed8119884 Pubmed8294403 Reactome Database ID Release 43453111 Reactome, http://www.reactome.org ReactomeREACT_23828 Reviewed: Dooms, H, 2011-03-17 Reviewed: Villarino, A, 2011-02-11 Shc is tyrosine phosphorylated by an unidentified kinase, creating a docking site for the SH2 domain of Grb2 (Zhu et al. 1994). Grb2 is an adaptor protein believed to be constitutively associated with the guanine nucleotide exchange protein Sos1 (often abbreviated to Sos). Recruitment of the Grb2:Sos1 complex leads to activation of the Ras pathway (Ravichandran & Burakoff 1994) and consequently activation of the MAPK pathway. has a Stoichiometric coefficient of 4 GRB2:SOS1 Interleukin receptor complexes with activated SHC1 Interleukin receptor complexes with activated SHC1:GRB2:SOS1