SREBP1A/1C/2 cleaved by S1P SREBP1A/1C/2 cleaved by S2P S2P Cleaves SREBP1A/1C/2 Authored: May, B, 2011-09-28 Edited: May, B, 2011-09-28 Pubmed10805775 Pubmed8156598 Pubmed8674110 Pubmed9659902 Reactome Database ID Release 431655851 Reactome, http://www.reactome.org ReactomeREACT_147876 Reviewed: Liang, Guosheng, 2012-08-25 S2P Cleaves SREBF1A/1C/2 S2P(MBTPS2), a membrane-bound protease in the Golgi, cleaves within the transmembrane region of SREBP1A/1C/2 (SREBF1A/1C/2), releasing the N-terminal domain of SREBP1A/1C/2 into the cytosol.