SREBP1A/1C/2 Transits to the Nucleus Authored: May, B, 2011-09-28 Edited: May, B, 2011-09-28 Pubmed10397761 Pubmed11283257 Pubmed14645851 Pubmed15550381 Pubmed8156598 Pubmed8674110 Pubmed9634703 Reactome Database ID Release 431655831 Reactome, http://www.reactome.org ReactomeREACT_147887 Reviewed: Liang, Guosheng, 2012-08-25 SREBF1A/1C/2 Transits to the Nucleus The N-terminal domain of SREBP1A/1C/2 (SREBF1A/1C/2) dimerizes and is imported from the cytosol into the nucleus by importin-beta (Nagoshi et al. 1999, Nagoshi and Yoned 2001, Lee et al. 2003). In the nucleus the dimers bind DNA (Parraga et al. 1998) and activate transcription (Datta and Osborne 2005). SREBP1A/1C/2:Importin beta-1 SREBP1A/1C/2:Importin beta-1