SREBP1A/2 Binds the HMGCR Promoter Authored: May, B, 2012-07-26 Edited: May, B, 2012-07-26 Pubmed18559965 Pubmed18654640 Pubmed8647822 Pubmed9748295 Reactome Database ID Release 432426162 Reactome, http://www.reactome.org ReactomeREACT_147894 Reviewed: Liang, Guosheng, 2012-08-25 SREBF1A/2 Binds the HMGCR Promoter SREBP1A (SREBF1A) or SREBP2, together with NF-Y, bind and transactivate the promoter of the HMGCR gene (Vallett et al. 1996, Pai et al. 1998, Reed et al. 2008, Rome et al. 2008). SREBP2 activates HMGCR slightly more than does SREBP1A (Pai et al. 1998). SREBP1A/2 binds 2 main sites and 2 auxiliary sites in the HMGCR promoter (Vallett et al. 1996). HMGCR gene NF-Y SREBP1A/2 Dimer SREBP1A/2:NF-Y:HMGCR gene