IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 p-STAT1 dimer bound to p-IFNGR1 p-STAT1:p-STAT1 dimer Release of STAT1 dimer from active receptor unit Authored: Garapati, P V, 2010-06-08 Edited: Garapati, P V, 2010-07-07 Pubmed12915721 Pubmed18591661 Pubmed7510216 Reactome Database ID Release 43873927 Reactome, http://www.reactome.org ReactomeREACT_24944 Reviewed: Abdul-Sater, AA, Schindler, C, 2010-08-17 The phosphorylated STAT1 on IFNGR1 chains homodimerize through reciprocal SH2-phosphotyrosine interactions to form p-STAT1 homodimer called gamma-activated-factor (GAF). This phosphorylated STAT1 homodimer disassociates from the receptor complex and translocates to the nucleus.