IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:p-STAT1 IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:STAT1 Dephosphorylation of STAT1 by SHP2 Authored: Garapati, P V, 2010-07-07 EC Number: 3.1.3.48 Edited: Garapati, P V, 2010-07-07 Pubmed10022928 Pubmed18508557 Reactome Database ID Release 43997309 Reactome, http://www.reactome.org ReactomeREACT_24939 Reviewed: Abdul-Sater, AA, Schindler, C, 2010-08-17 SHP2 negatively regulates the IFN-induced JAK-STAT pathway by dephosphorylating STAT1 on Y701.