IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2 IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:TYK2 Dephosphorylation of TYK2 by PTP1B Authored: Garapati, P V, 2010-07-07 EC Number: 3.1.3.48 Edited: Garapati, P V, 2010-07-07 Pubmed11694501 Reactome Database ID Release 43997311 Reactome, http://www.reactome.org ReactomeREACT_25329 Reviewed: Abdul-Sater, AA, Schindler, C, 2010-08-17 TYK2 bears the substrate recognition motif for PTP1B, and on IFN stimulation PTP1B interacts with and dephosphorylates TYK2.