ISGF3 ISGF3 bound to ISRE promotor elements ISGF3 binds the ISRE promoter elements in IFN-stimulated genes Authored: Garapati, P V, 2010-07-07 Edited: Garapati, P V, 2010-07-07 Effects of IFNs result from induction of a subset of genes, called IFN stimulated genes (ISGs). These ISGs are mainly implicated in anti-viral, anti-angiogenic, immunomodulatory, cell cycle inhibitory effects and apoptotic functions. All IFNA/B-stimulated genes have a conserved region of about 15bp in their promoter called the Interferon Stimulation Response Element (ISRE). The transcription factor ISGF3 binds to this ISRE and induce the transcription of these genes by IFN. Pubmed12766484 Pubmed18575461 Pubmed7540766 Pubmed9861020 Reactome Database ID Release 431015699 Reactome, http://www.reactome.org ReactomeREACT_24942 Reviewed: Abdul-Sater, AA, Schindler, C, 2010-08-17 ISRE promoter elements in type I IFN-regulated genes