IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2 AAF Formation of p-STAT1 homodimer Authored: Garapati, P V, 2010-07-07 EC Number: 2.7.10 Edited: Garapati, P V, 2010-07-07 Pubmed17351669 Pubmed7510216 Reactome Database ID Release 43909718 Reactome, http://www.reactome.org ReactomeREACT_25105 Reviewed: Abdul-Sater, AA, Schindler, C, 2010-08-17 Under certain conditions type I IFNs, IFNA/B are able to activate genes through a second STAT-based signaling cascade enabling the formation of p-STAT1:p-STAT1 homodimers called IFNA-activated-factor (AAF). has a Stoichiometric coefficient of 2