AAF AAF Translocation of p-STAT1:p-STAT1 dimer to nucleus Authored: Garapati, P V, 2010-07-07 Edited: Garapati, P V, 2010-07-07 IFNA-activated-factor (AAF) translocates to nucleus and then promotes the expression of a distinct set of gamma activated sequence (GAS)-driven genes like IRF1. IRF1, in turn, induces the transcription of ISG15, ISG54 and IFI6 genes. This second pathway of STAT1 homodimer formation is primarily activated by IFNG and is likely to account for some of the functional overlap between type I and type II IFNs. Pubmed7510216 Reactome Database ID Release 43913529 Reactome, http://www.reactome.org ReactomeREACT_25256 Reviewed: Abdul-Sater, AA, Schindler, C, 2010-08-17