ISGylation of protein translation regulator 4EHP 4EHP is a member of eukaryotic translation initiation factor 4E (eIF4E) family that acts as an mRNA 5' cap structure-binding protein and suppresses translation. 4EHP is one of the targets of ISG15 and ISGylated 4EHP has a much higher cap structure-binding activity. Authored: Garapati, P V, 2011-01-18 Edited: Garapati, P V, 2011-01-18 Pubmed17289916 Reactome Database ID Release 431678843 Reactome, http://www.reactome.org ReactomeREACT_115679 Reviewed: Zhang, DE, 2011--0-2- ISGylated 4EHP ISG15:UBCH8:ISG15 E3 ligase