Proteolytic PAK-2p34 fragment translocates to the nucleus Authored: Jakobi, R, 2008-02-05 11:04:14 Edited: Matthews, L, 2008-02-03 20:50:13 Edited: Matthews, L, 2008-05-18 16:50:19 Pubmed12853446 Reactome Database ID Release 43211712 Reactome, http://www.reactome.org ReactomeREACT_13409 Reviewed: Chang, E, 2008-05-21 00:05:41 The subcellular localization of PAK-2 is controlled by nuclear localization and nuclear export signal motifs (Jakobi et al.,2003). The regulatory domain contains a nuclear export signal motif that prevents the nuclear accumulation of full-length PAK-2. The activating proteolytic cleavage disrupts the nuclear export signal in PAK-2 and removes most its regulatory domain. The resulting activated PAK-2p34 fragment contains a nuclear localization signal and translocates to and is retained in the nucleus (Jakobi et al.,2003).