ISGylation of host protein filamin B Authored: Garapati, P V, 2011-01-18 EC Number: 6.3.2.19 Edited: Garapati, P V, 2011-01-18 ISG15 negatively regulates the scaffold protein filamin B. In response to type I IFNs, filamin B recruits RAC1, MEKK1, and MKK4, enhancing their sequential activation and thereby promoting JNK activation and apoptosis. ISGylation of filamin B leads to the disassociation of RAC1, MEKK1, and MKK4 from the scaffold, preventing type I IFN dependent JNK activation and apoptosis. It has been suggested that this inhibition of apoptosis may protect uninfected bystander cells from IFN-mediated apoptosis (Jeon et al, 2009). Pubmed12582176 Pubmed16009940 Pubmed19270716 Pubmed20153823 Pubmed20946978 Reactome Database ID Release 431169398 Reactome, http://www.reactome.org ReactomeREACT_115658 Reviewed: Zhang, DE, 2011--0-2- ISG15 E3 ligases ISG15:UBCH8:ISG15 E3 ligase ISGylated Filamin B