ISGylation of E2 conjugating enzymes Authored: Garapati, P V, 2011-01-18 EC Number: 6.3.2.19 Edited: Garapati, P V, 2011-01-18 Pubmed16112642 Pubmed16122702 Pubmed16428300 Pubmed20153823 Reactome Database ID Release 431169402 Reactome, http://www.reactome.org ReactomeREACT_115543 Reviewed: Zhang, DE, 2011--0-2- Ubiquitin conjugating E2 enzymes UBC13 and UBCH6 are targets for ISGylation. This suppresses the ubiquitin-conjugating activity of both UBC13 and UBCH6. This modification may play an important role in the control of signal transduction pathways, such as the NF-kB pathway, which are associated with K63-linked polyubiquitination (Takeuchi et al, 2005). ISG15 E3 ligases E2 congugating enzymes ISG15:UBCH8:ISG15 E3 ligase ISGylated E2 conjugating enzymes