Interaction of E3 ligase with ISG15:E2 complex Authored: Garapati, P V, 2011-01-18 Edited: Garapati, P V, 2011-01-18 Pubmed16352599 Pubmed16407192 Pubmed16815975 Pubmed17289916 Reactome Database ID Release 431169403 Reactome, http://www.reactome.org ReactomeREACT_116157 Reviewed: Zhang, DE, 2011--0-2- Ubiquitin ligase HERC5/CEB1 appears to be the predominant E3 ligase for ISGylation; EFP and HHARI/ARIH1 have also been reported as ISG15 E3 ligases. The E3 ligase recognizes specific target substrates and mediates the transfer of ISG15 from E2 to the substrate. ISG15 E3 ligases ISG15:UBCH8 ISG15:UBCH8:ISG15 E3 ligase