p-STAT1 homodimer PIAS1 binds p-STAT1 dimer Authored: Garapati, P V, 2010-06-08 Edited: Garapati, P V, 2010-07-07 PIAS1 protein interacts directly with phoshorylated STAT1 dimers and inhibit the transcriptional activity of STAT1 by blocking the DNA-binding domain of STAT1. It has also been suggested that PIAS proteins might regulate transcription by promoting small ubiquitin-related modifier (SUMO1) conjugation of STAT1. The significance of STAT1 sumoylation in regulating STAT1 activity is controversial and needs to be clarified. Pubmed10805787 Pubmed12855578 Pubmed18031232 Reactome Database ID Release 43877281 Reactome, http://www.reactome.org ReactomeREACT_25331 Reviewed: Abdul-Sater, AA, Schindler, C, 2010-08-17 p-STAT1 dimer:PIAS:SUMO1