IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3 IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2 SOCS-1 and SOCS-3 binds to p-JAK2 Authored: Garapati, P V, 2010-06-08 Edited: Garapati, P V, 2010-07-07 Pubmed10064597 Pubmed10421843 Reactome Database ID Release 43877269 Reactome, http://www.reactome.org ReactomeREACT_25158 Reviewed: Abdul-Sater, AA, Schindler, C, 2010-08-17 SOCS-1 and SOCS-3 coprecipitates with JAK kinases upon IFNG stimulation and are able to inhibit the JAK-STAT pathway, although with different affinity and kinetics. SOCS1 and SOCS3 binds to phosphorylated JAK1/2 and prevent the tyrosine kinase activity of JAKs through their kinase inhibitory region (KIR), thereby inhibiting downstream IFNG signaling. SOCS1 may also prevent IFNG signaling by targeting the signaling machinery to ubiquitin-proteasomal degradation pathway. SOCS-1 and SOCS-3