IFNG:IFNGR complex IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 Dephosphorylation of JAKs by PTPs Authored: Garapati, P V, 2010-06-08 EC Number: 3.1.3.48 Edited: Garapati, P V, 2010-07-07 Protein tyrosine phosphatases (PTPs) SHP1 and SHP2 down regulate the IFNG signaling by dephosphorylating the tyrosine residues critical to the activation of JAK kinases. PTP1B interacts directly with JAK2 but not JAK1 and dephosphorylate the tyrosine Y1007 on JAK2. Pubmed8943354 Reactome Database ID Release 43877308 Reactome, http://www.reactome.org ReactomeREACT_25190 Reviewed: Abdul-Sater, AA, Schindler, C, 2010-08-17 has a Stoichiometric coefficient of 2